T&D Bilirubin
Quantitative determination of bilirubin
CLINICAL SIGNIFICANCE
Bilirubin is a breakdown product of hemoglobin, insoluble in water. It is transported from the spleen to the liver and excreted into bile. Hyperbilirubinemia results from the increase of bilirubin concentrations in plasma.
Causes of hyperbilirubinemia:
Total bilirubin: Increase hemolysis, genetic errors, neonatal jaundice, ineffective erythrpoiesis, and drugs.
Direct bilirubin: Hepatic cholestasis, genetic errors, hepatocellular damage.
Clinical diagnosis should not be made on a single test result; it should integrate clinical and other laboratory data.
REAGENTS
|
R1 |
Sulfanilic acid Hydrochloric acid (HCl) |
30 mmol/L 150 mmol/L |
|
R2 |
Sodium nitrite |
29 mmol/L |
REFERENCE VALUES
- Total Bilirubin: 3 - 17 μmol/L.
- Direct Bilirubin: 0,1 - 4,2 μmol/L.
These values are for orientation purpose; each laboratory should establish its own reference range.
PACKAGING
- Ref: 1001044 - R1: 2 x 150 mL R2: 1 x 10 mL